1-Boc-4-(2-hydroxyethyl)piperidine

  • Name: 1-Boc-4-(2-hydroxyethyl)piperidine
  • CAS: 89151-44-0
  • Purity: 99%
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Quality products?make an important contribution to long-term revenue and profitability. Cost-effective and customizable 1-Boc-4-(2-hydroxyethyl)piperidine 89151-44-0 in stock

1.What is the 1-Boc-4-(2-hydroxyethyl)piperidine ?

N-BOC-4-piperidine-β-ethanol is used to prepare anilinoquinazoline VEGF receptor tyrosine kinase inhibitors with antitumor activities. It is also used to synthesize 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists with antiviral activities.

tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate
135716-08-4

tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate

4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester
89151-44-0

4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester

Conditions
Conditions Yield
tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate; With palladium 10% on activated carbon; hydrogen; In methanol; under 3040.2 Torr; Inert atmosphere;
With diisobutylaluminium hydride; In diethyl ether; at -20 ℃; for 0.166667h;
86%
Multi-step reaction with 2 steps
1: H2 / Pd/C / methanol / 20 °C
2: LAH / tetrahydrofuran / 20 °C
With lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;
Multi-step reaction with 2 steps
1: hydrogen / palladium 10% on activated carbon / ethanol / 12 h / 20 °C / Inert atmosphere
2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C
With lithium aluminium tetrahydride; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol;
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / 10 h / 60 °C / 15001.5 Torr
2: lithium borohydride / 21 h / Reflux
With lithium borohydride; palladium 10% on activated carbon; hydrogen;
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 20 °C
2: lithium triethylborohydride / tetrahydrofuran / 1 h / -78 - 1 °C / Inert atmosphere
With palladium 10% on activated carbon; hydrogen; lithium triethylborohydride; In tetrahydrofuran; ethanol;
Multi-step reaction with 2 steps
1: palladium-carbon catalyst / methanol
2: tetrahydrofuran
palladium-carbon catalyst; In tetrahydrofuran; methanol;
tert-butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate
135716-09-5

tert-butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate

4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester
89151-44-0

4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester

Conditions
Conditions Yield
With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;
100%
With lithium triethylborohydride; In tetrahydrofuran; at -78 - 1 ℃; for 1h; Inert atmosphere;
91%
With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;
tert-butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.333333h;
With water; sodium sulfate; In tetrahydrofuran; for 0.5h;
With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;
tert-butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate; With sodium tetrahydroborate; In tetrahydrofuran; for 0.5h; Reflux;
With methanol; In tetrahydrofuran; for 20h; Reflux;
With lithium borohydride; for 21h; Reflux;
108g

2.What is the CAS number for 1-Boc-4-(2-hydroxyethyl)piperidine ?

The CAS number of 1-Boc-4-(2-hydroxyethyl)piperidine is 89151-44-0.

More information of 1-Boc-4-(2-hydroxyethyl)piperidine 89151-44-0 are:

CAS?Number

89151-44-0

Density

1.043 g/cm3

Boiling Point

324.066 °C at 760 mmHg

Flash Point

149.79 °C

Vapor Pressure

0mmHg at 25°C

Refractive Index

n20/D 1.4730(lit.)

HS CODE

2933399090

PSA

49.77000

LogP

1.95380

Pka

15.10±0.10(Predicted)

3.What are another words for 1-Boc-4-(2-hydroxyethyl)piperidine ?

Synonyms?for?1-Boc-4-(2-hydroxyethyl)piperidine 89151-44-0:4-(2-Hydroxyethyl)-1-(tert-butoxycarbonyl)piperidine;4-(2-Hydroxyethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester;N-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidine;N-BOC-4-piperidine-b-ethanol;N-Boc-4-piperidineethanol;tert-Butyl4-(2-hydroxyethyl)tetrahydropyridine-1(2H)-carboxylate;1,1-Dimethylethyl4-(2-hydroxyethyl)-1-piperidinecarboxylate;1-tert-Butoxycarbonyl-4-piperidineethanol;2-(N-tert-Butoxycarbonyl-4-piperidinyl)ethanol;

4.What is the molecular formula of 1-Boc-4-(2-hydroxyethyl)piperidine?

The chemical formula of ?1-Boc-4-(2-hydroxyethyl)piperidine is?C12H23NO3 which containing 12 Carbon atoms,23 Hydrogen atoms,1 Nitrogen atoms and 3 Oxygen atoms,and the molecular weight of??1-Boc-4-(2-hydroxyethyl)piperidine?is 229.32.

5.What is 1-Boc-4-(2-hydroxyethyl)piperidine (89151-44-0) used for?

1-Boc-4-(2-hydroxyethyl)piperidine, also known as N-BOC-4-piperidine-β-ethanol, is an organic compound that serves as an important intermediate in the synthesis of various pharmaceuticals and bioactive molecules. It features a piperidine ring with a 2-hydroxyethyl side chain and a Boc-protecting group, which plays a crucial role in the compound's reactivity and stability during chemical reactions.

InChI:InChI=1/C12H23NO3/c1-12(2,3)16-11(15)13-7-4-10(5-8-13)6-9-14/h10,14H,4-9H2,1-3H3

Relevant articles related to 1-Boc-4-(2-hydroxyethyl)piperidine:

Article

Source

Discovery of a Novel, Highly Potent, and Selective Thieno[3,2- d]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor Agent

Kurasawa, Osamu,Miyazaki, Tohru,Homma, Misaki,Oguro, Yuya,Imada, Takashi,Uchiyama, Noriko,Iwai, Kenichi,Yamamoto, Yukiko,Ohori, Momoko,Hara, Hideto,Sugimoto, Hiroshi,Iwata, Kentaro,Skene, Robert,Hoffman, Isaac,Ohashi, Akihiro,Nomura, Toshiyuki,Cho, Nobuo

, p. 1084 - 1104 (2020/02/05)

Agent for Preventing or Ameliorating Hearing Impairment

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Paragraph 0093; 0094; 0116-0117, (2019/08/02)

6.Buy 1-Boc-4-(2-hydroxyethyl)piperidine with the best price .

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